Late breaking phase II olpasiran data from OCEAN(a)-DOSE study is presented at European Society of Cardiology annual meeting.- Amgen

In the off-treatment extension period, olpasiran showed a lasting effect on Lp(a) reduction nearly a year after the last dose. Results from the OCEAN(a)-DOSE Phase II study announced in November of 2022 showed that doses of olpasiran greater than 75 mg Q12W reduced patients' Lp(a) by greater than 95% at week 36. The results from the off-treatment extension period show that patients previously dosed with greater than 75 mg of olpasiran sustained a ~40-50% placebo-adjusted percent reduction in Lp(a) nearly a year after the last dose. No new safety concerns were identified during the off-treatment extension period.

Additionally, this study was the first to explore the effects of olpasiran on a key biomarker strongly associated with atherosclerosis, pro-atherogenic OxPL-apoB [Oxidized Phospholipids (Ox-PL) on apoB-100 (apoB)]. During the treatment period, olpasiran showed a dose-dependent reduction in pro-atherogenic OxPL-apoB.

"Additional results from the OCEAN(a)-DOSE study continue to be encouraging, as they tell us olpasiran not only robustly reduces Lp(a) levels, but that it has a long-lasting effect on this important risk factor for ASCVD (atherosclerotic cardiovascular disease)," said Michelle L. O'Donoghue, MD, MPH, associate professor, Harvard Medical School, Cardiovascular Medicine and lead investigator of the OCEAN(a)-DOSE study. "Additionally, we were able to show that olpasiran reduced OxPL-apoB, further adding to the potential of RNA interference with olpasiran as a promising treatment approach to reducing elevated Lp(a)."

LDL Awareness to Action Implementation Consortium : Amgen is committed to working with stakeholders to achieve the goal of reducing cardiovascular disease globally and, this year at ESC, convened a new LDL Awareness to Action Implementation Consortium (LATAIC). LATAIC is focused on improving LDL-C testing and evidence-based treatment through identification of opportunities to accelerate efficiency and impact of the translation of evidence-based research into clinical practice. The consortium is comprised of leading CV institutions, including Duke, Harvard's BAIM Institute, Johns Hopkins, Geisinger, University of Colorado, St. Luke's, Brigham and Women's Hospital, Providence, Yale and UT Southwestern.