Publication of Olinvyk respiratory physiology study in Anesthesiology journal
Trevena, Inc. announced the publication of Olinvyk data in the peer-reviewed journal Anesthesiology
The paper, entitled “Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic-Pharmacodynamic Comparison with Morphine” was published in collaboration with researchers at several prestigious institutions, including the Leiden University Medical Center in the Netherlands.
The paper summarizes the key findings of the four-arm, double-blind, randomized crossover study of eighteen 56- to 87-year-old male and female participants. The intent of the study was to evaluate the difference between oliceridine and IV morphine as measured by the effect on ventilation. The results of the study demonstrated that oliceridine and morphine differed in their pharmacodynamics with a more rapid onset and offset of respiratory depression for oliceridine and a smaller magnitude of respiratory depression over time The total number of adverse events was similar between the two opioids. The most frequently reported adverse events for oliceridine were dizziness, lightheadedness, somnolence and horizontal vertigo; for morphine, the most frequently reported adverse events were nausea, lightheadedness, dizziness and somnolence.
“These important results further suggest that the pharmacodynamic characteristics of oliceridine may provide a reduced impact on ventilatory function as compared to IV morphine,” said Dr. Albert Dahan, Professor of Anesthesiology at Leiden University Medical Center. “We are pleased to share the results of our work with a broader scientific audience.”
“This publication is complementary to the other datasets highlighting Olinvyk’s potential difference with regard to respiratory effects on patients,” said Mark A. Demitrack, M.D., Senior Vice President and Chief Medical Officer of Trevena. “We believe Dr. Dahan’s paper highlights how age can affect these differences. These data may be relevant in the clinical care of elderly patients.”
As with all opioids, serious, life-threatening, or fatal respiratory depression may occur in patients treated with Olinvyk as indicated in the boxed warning.
See-"Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine"-Pieter Simons, M.D., Rutger van der Schrier, M.D., Maarten van Lemmen, B.Sc.,et.al.,. Publication: Anesthesiology Anesthesiology. March 2023: 138(3):249–263 DOI: https://doi.org/10.1097/ALN.0000000000004473.
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