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Smoking cessation

Last updated: 2nd Sep 2025

Quitting smoking is one of the most impactful decisions a person can make for their health – but it is rarely easy. Tobacco use is a chronic, relapsing condition driven by both physiological nicotine dependence and deeply ingrained behavioral patterns. Despite global declines in smoking rates, millions still smoke, and many want to stop. Importantly, continued smoking not only harms the individual but also exposes others to secondhand smoke, which remains a significant public health concern – particularly for children and vulnerable adults, who are most susceptible to its harmful effects.


How many people smoke globally?

Globally, an estimated 1.3 billion people use tobacco, with nearly 80% residing in low- and middle-income countries.


What symptoms are commonly associated with smoking cessation?

Withdrawal symptoms include cravings, irritability, restlessness, difficulty concentrating, insomnia, weight gain, and mood changes.


What are the core management strategies for effective smoking cessation?

Smoking cessation is primarily supported by pharmacologic and behavioral interventions, with combination therapy being the most effective when tailored to individual needs to reduce relapse risk. Nicotine replacement therapies – including patches, lozenges, gum, inhalers, and nasal sprays – are commonly used alongside non-pharmacologic approaches, such as cognitive behavioral therapy, motivational interviewing, and reinforcement strategies, to promote sustained behavior change. In addition to nicotine-based options, prescription medicines – such as a partial nicotinic receptor agonist and an atypical antidepressant that modulates dopaminergic and noradrenergic activity – may further improve quit rates, especially in individuals with a history of failed attempts or comorbid conditions.


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