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mCRPC in Focus

Expert opinions on mCRPC management

Last updated: 19th Aug 2025
Published: 28th Aug 2024

Topics in mCRPC management: Unmet needs, guidelines, clinical trials

mCRPC management unpacked: Imaging, genetic testing, and treatment decisions

“The complexity [of mCRPC] requires multidisciplinary care,” says Neal Shore. When should germline testing be considered? How can PSMA PET imaging be effectively integrated into clinical decision-making? Watch as leading experts explore key challenges in access, workflow inefficiencies, and the evolving role of imaging and genetic testing in mCRPC management. View transcript.

“The complexity [of mCRPC] requires multidisciplinary care,” says Neal Shore. When should germline testing be considered? How can PSMA PET imaging be effectively integrated into clinical decision-making? Watch as leading experts explore key challenges in access, workflow inefficiencies, and the evolving role of imaging and genetic testing in mCRPC management. View transcript.

Can investigational treatments address unmet needs in mCRPC?

Can investigational therapies enable mCRPC treatment in an “all-comer” patient population? Axel Merseburger (University Hospital Schleswig-Holstein, Campus Lübeck, Germany) reflects on this and other possibilities. View transcript.

Can investigational therapies enable mCRPC treatment in an “all-comer” patient population? Axel Merseburger (University Hospital Schleswig-Holstein, Campus Lübeck, Germany) reflects on this and other possibilities. View transcript.

Barriers to uptake of clinical practice guidelines for mCRPC

Axel Merseburger discusses some key challenges in following clinical practice guideline recommendations for mCRPC management, and why guideline uptake remains low. View transcript.

Axel Merseburger discusses some key challenges in following clinical practice guideline recommendations for mCRPC management, and why guideline uptake remains low. View transcript.

Important considerations about patient populations in mCRPC trials

Neeraj Agarwal (Huntsman Cancer Institute, University of Utah, USA) identifies an important caveat for patient populations in phase 3 first-line mCRPC trials, which he considers “the single most debated point” at conferences. View transcript.

Neeraj Agarwal (Huntsman Cancer Institute, University of Utah, USA) identifies an important caveat for patient populations in phase 3 first-line mCRPC trials, which he considers “the single most debated point” at conferences. View transcript.

Differences in clinical trial design for PARP inhibitors and novel hormonal therapies

Neeraj Agarwal describes similarities and differences in the design of the MAGNITUDE, TALAPRO-2, and PROpel mCRPC trials, noting all trials were “inherently different” and their similarities stop after three common features. View transcript.

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Neeraj Agarwal describes similarities and differences in the design of the MAGNITUDE, TALAPRO-2, and PROpel mCRPC trials, noting all trials were “inherently different” and their similarities stop after three common features. View transcript.

Please answer the following questions before you read on (not mandatory). This helps us improve the educational design of our resources.

1. According to the National Comprehensive Cancer Network, talazoparib plus enzalutamide is an option for patients with metastatic castration-resistant prostate cancer (mCRPC) and
2. Genomic changes leading to dysfunction of the cell-cycle regulators RB1 and/or cyclin-dependent kinases are present in up to what percentage of patients with mCRPC?
3. Why did the European Medicines Agency withdraw marketing authorization for sipuleucel-T in 2015?
4. A recent study revealed that some patients with mCRPC are willing to trade survival time for improvement in other outcomes. How much survival time are some patients prepared to trade for elimination of moderate nausea?

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