This site is intended for healthcare professionals
Photomicrograph of a CT (CAT) scan-guided needle core biopsy showing pulmonary squamous cell carcinoma, a type of non-small cell carcinoma, cell image, pink and purple colours
Molecular diagnostics for RET inhibition in NSCLC and thyroid cancers

Expert opinion

Last updated: 9th Sep 2021
Published: 9th Sep 2021

RET inhibitors are an exciting development in the fight against non-small cell lung cancer (NSCLC) and thyroid cancers. Watch our expert interviews:

  • Dr Alexander Drilon discusses the impact of RET inhibitors for NSCLC
  • Professor Lori Wirth introduces RET inhibitors in the management of thyroid cancers
  • Professor Fernando Lopez-Rios explains molecular testing for RET alterations

RET inhibitors in non-small cell lung cancer

Dr Alexander Drilon, the Chief of the Early Drug Development Service and an Associate Attending Physician of the Thoracic Oncology Service at Memorial Sloan Kettering Cancer Center in New York City, USA, discusses RET inhibitors as a treatment for non-small cell lung cancer (NSCLC).

The importance of molecular testing for RET inhibition in NSCLC
1

Evidence of the effectiveness of RET inhibitors for treating NSCLC
2

What ongoing clinical trials are underway for RET inhibitors in NSCLC?
The main side effects of RET inhibitors in NSCLC and how to address them
2

Real-world challenges of NSCLC management: patient stratification and molecular testing for RET alterations
2

RET gene status in NSCLC patients: testing strategies and results interpretation
2

RET inhibitors in thyroid cancer

Professor Lori Wirth, Associate Professor of Medicine at Harvard Medical School and Medical Director of the Center for Head and Neck Cancers at Massachusetts General Hospital, Boston, USA, discusses the use of RET inhibitors to treat thyroid cancers.

The importance of molecular testing for RET inhibition in thyroid cancer
1

The relevance of RET inhibition for thyroid cancer management
Prevalence of RET alterations in thyroid cancers
1

Evidence of the effectiveness of RET inhibitors for treating thyroid cancer
What relevant clinical trials are currently underway in medullary thyroid cancer (MTC)?
2

The main side effects of RET inhibitors in thyroid cancers and how to address them
Stratifying thyroid cancer patients for RET inhibitor treatment
3

Real-world challenges of thyroid cancer management: patient stratification and molecular testing for RET alterations
RET gene status in thyroid cancer patients: testing strategies and results interpretation
2

Molecular testing for RET alterations

Join Professor Fernando Lopez-Rios, a professor of Pathology and Molecular Pathology from Spain, to learn why it is important to test for rearranged during transfection (RET) gene alterations in patients with non-small cell lung cancer (NSCLC) and thyroid cancer.

Prevalence of RET alterations in NSCLC and thyroid cancers
2

The challenges of patient stratification and molecular testing for RET alterations
2

Molecular testing techniques for RET alteration detection
NSCLC sample requirements for RET alteration detection
2

Thyroid cancer sample requirements for RET alteration detection
The clinical sample journey for assessing RET alterations
3

Molecular testing for RET alteration: navigating the results
2